Protein profile

PA1699

hypothetical protein

Genome: NC_002516.2

Gene: PA1699 Structure source: AlphaFold UniProt G3XCT8

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Amino acids 92

Annotations 2

Features 8

PDB binders 0

Druggability 0.802

Overview

Basic information about this protein and its source genome.

Accession: PA1699
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1699
Status: annotated
Amino acids: 92
Structure source: AlphaFold

GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.802

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
6	86	Pfam	PF09059	TyeA
6	86	InterPro	IPR015144	Type III secretion system effector delivery regulator TyeA
1	91	Gene3D	G3DSA:1.20.1280.80	-
1	91	InterPro	IPR038347	TyeA superfamily
1	91	FunFam	G3DSA:1.20.1280.80:FF:000001	SepL/TyeA/HrpJ family type III secretion system gatekeeper
4	84	NCBIfam	TIGR02511	TyeA family type III secretion system gatekeeper subunit
4	84	InterPro	IPR013351	Type III secretion system effector delivery regulator TyeA-related
2	90	SUPERFAMILY	SSF140591	Type III secretion system domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1699	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.802