Protein profile

PA1703

type III secretory apparatus protein PcrD

Genome: NC_002516.2

Gene: pcrD PA1703 Structure source: AlphaFold UniProt Q9I327
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Amino acids 706
Annotations 5
Features 52
PDB binders 0
Druggability 0.897

Overview

Basic information about this protein and its source genome.

Accession
PA1703
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pcrD PA1703
Status
annotated
Amino acids
706
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0009306 The controlled release of proteins from a cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
  • GO:0009306 The controlled release of proteins from a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

52 records
Show feature table
Start End DB Term Name
41 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 297 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
108 130 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
322 706 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
370 515 Gene3D G3DSA:3.40.30.60 FHIPEP family, domain 1
370 515 InterPro IPR042194 FHIPEP, domain 1
516 603 Gene3D G3DSA:1.10.8.540 FHIPEP family, domain 3
516 603 InterPro IPR042193 FHIPEP, domain 3
303 321 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
42 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 704 NCBIfam TIGR01399 type III secretion system export apparatus subunit SctV
14 704 InterPro IPR006302 Type III secretion protein HrcV
3 706 PIRSF PIRSF005419 FlhA
3 706 InterPro IPR001712 Type III secretion system FHIPEP
259 278 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
104 130 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 198 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71 93 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
298 302 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
220 230 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
68 92 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
8 705 PANTHER PTHR30161 FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED
8 705 InterPro IPR001712 Type III secretion system FHIPEP
232 246 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
232 246 InterPro IPR001712 Type III secretion system FHIPEP
151 169 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
151 169 InterPro IPR001712 Type III secretion system FHIPEP
33 46 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
33 46 InterPro IPR001712 Type III secretion system FHIPEP
132 148 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
132 148 InterPro IPR001712 Type III secretion system FHIPEP
181 198 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
181 198 InterPro IPR001712 Type III secretion system FHIPEP
70 89 PRINTS PR00949 Type III secretion system inner membrane A protein family signature
70 89 InterPro IPR001712 Type III secretion system FHIPEP
137 160 ProSitePatterns PS00994 Bacterial export FHIPEP family signature.
137 160 InterPro IPR025505 FHIPEP conserved site
36 40 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
240 262 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
199 219 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 35 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 38 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 16 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
606 704 Gene3D G3DSA:3.40.50.12790 FHIPEP family, domain 4
606 704 InterPro IPR042196 FHIPEP, domain 4
283 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
198 220 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
231 258 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
26 696 Pfam PF00771 FHIPEP family
26 696 InterPro IPR001712 Type III secretion system FHIPEP
93 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
62 67 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1703
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.897
7 0.454
1 0.304