Protein profile

PA1706

type III secretion protein PcrV

Genome: NC_002516.2

Gene: pcrV PA1706 Structure source: Experimental + AlphaFold UniProt G3XD49
Export view
Amino acids 294
Annotations 4
Features 23
PDB binders 0
Druggability 0.561

Overview

Basic information about this protein and its source genome.

Accession
PA1706
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pcrV PA1706
Status
annotated
Amino acids
294
Structure source
Experimental + AlphaFold
GO
GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.561
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
  • GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
108 128 PRINTS PR01592 Low calcium response V antigen signature
108 128 InterPro IPR005413 Low calcium response V antigen
250 269 PRINTS PR01592 Low calcium response V antigen signature
250 269 InterPro IPR005413 Low calcium response V antigen
30 55 PRINTS PR01592 Low calcium response V antigen signature
30 55 InterPro IPR005413 Low calcium response V antigen
206 226 PRINTS PR01592 Low calcium response V antigen signature
206 226 InterPro IPR005413 Low calcium response V antigen
87 105 PRINTS PR01592 Low calcium response V antigen signature
87 105 InterPro IPR005413 Low calcium response V antigen
156 179 PRINTS PR01592 Low calcium response V antigen signature
156 179 InterPro IPR005413 Low calcium response V antigen
131 153 PRINTS PR01592 Low calcium response V antigen signature
131 153 InterPro IPR005413 Low calcium response V antigen
228 249 PRINTS PR01592 Low calcium response V antigen signature
228 249 InterPro IPR005413 Low calcium response V antigen
269 291 PRINTS PR01592 Low calcium response V antigen signature
269 291 InterPro IPR005413 Low calcium response V antigen
121 141 Coils Coil Coil
26 293 SUPERFAMILY SSF103388 Virulence-associated V antigen
26 293 InterPro IPR036139 Virulence-associated V antigen superfamily
74 294 Pfam PF04792 V antigen (LcrV) protein
74 294 InterPro IPR005413 Low calcium response V antigen

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9JBQ
X-ray 2.00 Å C
45.6% 130-263
PDBe RCSB PDBj File
Viewing
PDB 9FM0
X-ray 2.56 Å E,F
40.1% 132-249
PDBe RCSB PDBj File
Loaded
AlphaFold PA1706
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.561
2 0.354
3 0.241