Protein profile

PA1707

regulatory protein PcrH

Genome: NC_002516.2

Gene: PA1707 pcrH Structure source: Experimental + AlphaFold UniProt Q9I325
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Amino acids 167
Annotations 3
Features 17
PDB binders 0
Druggability 0.483

Overview

Basic information about this protein and its source genome.

Accession
PA1707
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1707 pcrH
Status
annotated
Amino acids
167
Structure source
Experimental + AlphaFold
GO
GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.483
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 161 PIRSF PIRSF003165 Chaper_prot_SicA
1 161 InterPro IPR016379 Type III secretion system, low calcium response, chaperone LcrH/SycD, subgroup
29 134 SUPERFAMILY SSF48452 TPR-like
29 134 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
22 45 PRINTS PR01595 Gram-negative bacterial type III secretion SycD chaperone signature
22 45 InterPro IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD
103 125 PRINTS PR01595 Gram-negative bacterial type III secretion SycD chaperone signature
103 125 InterPro IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD
47 66 PRINTS PR01595 Gram-negative bacterial type III secretion SycD chaperone signature
47 66 InterPro IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD
71 93 PRINTS PR01595 Gram-negative bacterial type III secretion SycD chaperone signature
71 93 InterPro IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD
20 153 NCBIfam TIGR02552 SycD/LcrH family type III secretion system chaperone
20 153 InterPro IPR005415 Type III secretion system, low calcium response, chaperone LcrH/SycD
11 161 FunFam G3DSA:1.25.40.10:FF:000904 CesD/SycD/LcrH family type III secretion system chaperone
11 161 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
11 161 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2XCB
X-ray 1.85 Å A,B
83.8% 21-160
PDBe RCSB PDBj File
Viewing
PDB 2XCC
X-ray 2.13 Å A,B
83.8% 21-160
PDBe RCSB PDBj File
Loaded
AlphaFold PA1707
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.483
2 0.25

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.51 0.329
2 4.79 0.212
3 2.22 0.054