Protein profile

PA1710

exoenzyme S synthesis protein ExsC

Genome: NC_002516.2

Gene: exsC PA1710 Structure source: Experimental + AlphaFold UniProt P26995
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Amino acids 145
Annotations 3
Features 5
PDB binders 0
Druggability 0.533

Overview

Basic information about this protein and its source genome.

Accession
PA1710
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
exsC PA1710
Status
annotated
Amino acids
145
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.533
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
9 126 Pfam PF05932 Tir chaperone protein (CesT) family
9 126 InterPro IPR010261 Tir chaperone protein (CesT) family
4 129 SUPERFAMILY SSF69635 Type III secretory system chaperone-like
8 133 CDD cd17018 T3SC_IA_ExsC-like
1 133 Gene3D G3DSA:3.30.1460.10 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3KXY
X-ray 2.80 Å A,B,C,D,E,F,G,H,I,J,K,L
90.3% 1-131
PDBe RCSB PDBj File
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AlphaFold PA1710
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