Protein profile

PA1711

hypothetical protein

Genome: NC_002516.2

Gene: PA1711 exsE Structure source: Experimental + AlphaFold UniProt Q9I322
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Amino acids 81
Annotations 6
Features 6
PDB binders 0
Druggability 0.41

Overview

Basic information about this protein and its source genome.

Accession
PA1711
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1711 exsE
Status
annotated
Amino acids
81
Structure source
Experimental + AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0071277 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.41
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
  • GO:0071277 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
  • GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
33 78 Pfam PF18286 Type III secretion system ExsE
33 78 InterPro IPR040866 Type III secretion system ExsE
16 81 Gene3D G3DSA:6.20.290.10 -
1 21 MobiDBLite mobidb-lite consensus disorder prediction
1 80 NCBIfam NF033906 T3SS regulon translocated regulator ExsE family protein
59 81 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3KXY
X-ray 2.80 Å T,U,V,W,X,Y
81.5% 16-81
PDBe RCSB PDBj File
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AlphaFold PA1711
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