Protein profile

PA1712

exoenzyme S synthesis protein ExsB

Genome: NC_002516.2

Gene: exsB PA1712 Structure source: Experimental + AlphaFold UniProt P26994
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Amino acids 137
Annotations 1
Features 10
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
PA1712
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
exsB PA1712
Status
annotated
Amino acids
137
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
10 14 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
13 137 Gene3D G3DSA:2.60.40.2990 -
1 14 Phobius SIGNAL_PEPTIDE Signal peptide region
1 14 SignalP_EUK SignalP-noTM SignalP-noTM
2 9 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
15 137 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 125 NCBIfam TIGR02567 YscW family type III secretion system pilotin
21 114 Pfam PF09619 Type III secretion system lipoprotein chaperone (YscW)
21 114 InterPro IPR039366 Type 3 secretion system pilotin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2YJL
X-ray 1.81 Å A,B,C
91.2% 13-137
PDBe RCSB PDBj File
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AlphaFold PA1712
AlphaFold — — full sequence — Loaded
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