Protein profile

PA1713

exoenzyme S transcriptional regulator ExsA

Genome: NC_002516.2

Gene: exsA PA1713 Structure source: Experimental + AlphaFold UniProt P26993
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Amino acids 278
Annotations 8
Features 21
PDB binders 0
Druggability 0.809

Overview

Basic information about this protein and its source genome.

Accession
PA1713
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
exsA PA1713
Status
annotated
Amino acids
278
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.809
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0001216 A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0050709 Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
  • GO:2000144 Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
220 269 SUPERFAMILY SSF46689 Homeodomain-like
220 269 InterPro IPR009057 Homeobox-like domain superfamily
164 270 FunFam G3DSA:1.10.10.60:FF:000386 AraC family transcriptional regulator
191 268 Pfam PF12833 Helix-turn-helix domain
191 268 InterPro IPR018060 DNA binding HTH domain, AraC-type
171 269 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
171 269 InterPro IPR018060 DNA binding HTH domain, AraC-type
167 217 SUPERFAMILY SSF46689 Homeodomain-like
167 217 InterPro IPR009057 Homeobox-like domain superfamily
164 271 Gene3D G3DSA:1.10.10.60 -
6 83 Gene3D G3DSA:2.60.120.10 Jelly Rolls
6 83 InterPro IPR014710 RmlC-like jelly roll fold
184 267 SMART SM00342 aracneu4
184 267 InterPro IPR018060 DNA binding HTH domain, AraC-type
12 269 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
221 263 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
221 263 InterPro IPR018062 HTH domain AraC-type, conserved site
236 251 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
236 251 InterPro IPR020449 Transcription regulator HTH, AraC- type
251 267 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
251 267 InterPro IPR020449 Transcription regulator HTH, AraC- type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4ZUA
X-ray 2.50 Å A,B
63.7% 2-178
PDBe RCSB PDBj File
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AlphaFold PA1713
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.809
2 0.686
1 0.588

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.54 0.072
2 0.79 0.002