Protein profile

PA1717

type III export protein PscD

Genome: NC_002516.2

Gene: PA1717 pscD Structure source: Experimental + AlphaFold UniProt Q9I318
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Amino acids 432
Annotations 1
Features 14
PDB binders 0
Druggability 0.673

Overview

Basic information about this protein and its source genome.

Accession
PA1717
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1717 pscD
Status
annotated
Amino acids
432
Structure source
Experimental + AlphaFold
GO
GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.673
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MAWKIRFYSGLNQGAEVSLGEGRVALGSDPLQADLVLLDEGIAAVHLVLEVDAQGVRLLEWAEGCEPRQDGQAQVAGAILQALAGQTCGPLRWAFCDPQRSFPERFPEAEVQTAPVRRKSSARAGGAWLLGVSLALALCLLGMLVEPWSARQHGMAGEEPLAKVRAYLREQGMSEVDVQRQGDSLLLGGYLEDNARRLALQRYLDGSGVDYRLEARSMEDIRQGVDFILQKFGYRQILSSNADKPGWVRLNGELAEQDERWARIDALLESEVPGLLGVENQVRVAGSHLRRLERLLADAGLDRQLSFRERGERIELSGTLDEVQLSAFYRLQREFQQEFGNRPSLVLLSRGKRASGDELEFTIRSVSLGRVPYVVLGDGQKYPVGASTSRGVRILAIEPESILVARGKQRFIINLKGEVLHDDSLGNATVGR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
3 415 NCBIfam TIGR02500 type III secretion system inner membrane ring subunit SctD
3 415 InterPro IPR012843 Type III secretion system YscD/HrpQ
6 98 Pfam PF16697 Inner membrane component of T3SS, cytoplasmic domain
6 98 InterPro IPR032030 YscD, cytoplasmic domain
127 145 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 123 Gene3D G3DSA:2.60.200.20 -
154 217 Gene3D G3DSA:3.30.1340.30 -
126 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
146 432 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 126 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
287 349 Gene3D G3DSA:3.30.70.1770 -
218 285 Gene3D G3DSA:3.30.1340.30 -
164 415 Pfam PF16693 Inner membrane component of T3SS, periplasmic domain
164 415 InterPro IPR032034 Yop protein translocation protein D, periplasmic domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6UID
X-ray 1.45 Å A
29.2% 1-126
PDBe RCSB PDBj File
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AlphaFold PA1717
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