Protein profile

PA1719

type III export protein PscF

Genome: NC_002516.2

Gene: sctF PA1719 pscF Structure source: Experimental + AlphaFold UniProt P95434
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Amino acids 85
Annotations 5
Features 9
PDB binders 0
Druggability 0.436

Overview

Basic information about this protein and its source genome.

Accession
PA1719
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
sctF PA1719 pscF
Status
annotated
Amino acids
85
Structure source
Experimental + AlphaFold
GO
GO:0009986 The external part of the cell wall and/or plasma membrane. GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.436
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0009986 The external part of the cell wall and/or plasma membrane.
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
13 85 Pfam PF09392 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
13 85 InterPro IPR021123 Type III secretion, needle-protein-like
3 84 Gene3D G3DSA:1.20.58.90 -
3 84 FunFam G3DSA:1.20.58.90:FF:000014 Type III secretion apparatus needle protein YscF
13 85 NCBIfam TIGR02105 type III secretion system needle filament subunit SctF
13 85 InterPro IPR011841 Type III secretion system, needle protein
8 81 SUPERFAMILY SSF140129 MxiH-like
8 81 InterPro IPR037203 Type III secretion, needle-protein-like superfamily
17 41 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2UWJ
X-ray 2.00 Å F
36.5% 55-85
PDBe RCSB PDBj File
Viewing
AlphaFold PA1719
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.436
2 0.263

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.64 0.027