Protein profile

PA1721

type III export protein PscH

Genome: NC_002516.2

Gene: PA1721 pscH Structure source: AlphaFold UniProt Q9I316

Export view

Amino acids 143

Annotations 2

Features 7

PDB binders 0

Druggability 0.875

Overview

Basic information about this protein and its source genome.

Accession: PA1721
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1721 pscH
Status: annotated
Amino acids: 143
Structure source: AlphaFold

GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0030257 A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.
GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
54	142	Pfam	PF09025	YopR, type III needle-polymerisation regulator
54	142	InterPro	IPR013349	Type III secretion system effector YopR
16	141	NCBIfam	TIGR02509	YopR family T3SS polymerization control protein
16	141	InterPro	IPR013349	Type III secretion system effector YopR
24	123	SUPERFAMILY	SSF140591	Type III secretion system domain
27	127	Gene3D	G3DSA:1.10.10.1000	Type III secretion system virulence factor YopR, core domain
27	127	InterPro	IPR041814	Type III secretion system virulence factor YopR, core domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1721	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.875