Protein profile

PA1723

type III export protein PscJ

Genome: NC_002516.2

Gene: PA1723 pscJ Structure source: AlphaFold UniProt Q9I314
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Amino acids 248
Annotations 3
Features 31
PDB binders 0
Druggability 0.917

Overview

Basic information about this protein and its source genome.

Accession
PA1723
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1723 pscJ
Status
annotated
Amino acids
248
Structure source
AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. GO:0009306 The controlled release of proteins from a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.917
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
  • GO:0009306 The controlled release of proteins from a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
244 248 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25 190 Pfam PF01514 Secretory protein of YscJ/FliF family
25 190 InterPro IPR006182 Flagellar M-ring , N-terminal
23 94 Gene3D G3DSA:3.30.70.1530 Hypothetical protein rpa1041
10 195 NCBIfam TIGR02544 type III secretion inner membrane ring lipoprotein SctJ
10 195 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
28 221 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
97 202 Gene3D G3DSA:3.30.300.30 -
97 202 InterPro IPR045851 AMP-binding enzyme, C-terminal domain superfamily
80 93 PRINTS PR01338 Type III secretion system outer membrane K protein family signature
80 93 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
28 38 PRINTS PR01338 Type III secretion system outer membrane K protein family signature
28 38 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
169 181 PRINTS PR01338 Type III secretion system outer membrane K protein family signature
169 181 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
120 133 PRINTS PR01338 Type III secretion system outer membrane K protein family signature
120 133 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
100 115 PRINTS PR01338 Type III secretion system outer membrane K protein family signature
100 115 InterPro IPR003282 Type III secretion system lipoprotein HrcJ/YscJ
24 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
222 244 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
1 23 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 11 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
12 23 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
97 202 FunFam G3DSA:3.30.300.30:FF:000043 Lipoprotein
222 243 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
5 225 PANTHER PTHR30046 FLAGELLAR M-RING PROTEIN
5 225 InterPro IPR043427 Lipoprotein YscJ/Flagellar M-ring protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1723
AlphaFold — — full sequence — Viewing
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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.252