Protein profile

PA1725

type III secretion system protein

Genome: NC_002516.2

Gene: pscL PA1725 Structure source: AlphaFold UniProt Q9I312

Export view

Amino acids 214

Annotations 2

Features 6

PDB binders 0

Druggability 0.508

Overview

Basic information about this protein and its source genome.

Accession: PA1725
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: pscL PA1725
Status: annotated
Amino acids: 214
Structure source: AlphaFold

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.508

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
74	194	Pfam	PF02108	Flagellar assembly protein FliH
74	194	InterPro	IPR018035	Flagellar assembly protein FliH/Type III secretion system HrpE
19	187	NCBIfam	TIGR02499	type III secretion system stator protein SctL
19	187	InterPro	IPR012842	Type 3 secretion system stator protein SctL/SctL2
29	56	Coils	Coil	Coil
3	205	PANTHER	PTHR34982	YOP PROTEINS TRANSLOCATION PROTEIN L

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1725	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.508
2				0.472
1				0.349