Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1759
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1759
Status: annotated
Amino acids: 901
Structure source: AlphaFold

GO

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.893

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records

Show feature table

Start	End	DB	Term	Name
551	571	Coils	Coil	Coil
831	901	Gene3D	G3DSA:1.10.10.10	-
831	901	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
838	895	SMART	SM00421	luxrmega5
838	895	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
3	899	PANTHER	PTHR43214	TWO-COMPONENT RESPONSE REGULATOR
3	899	InterPro	IPR039420	Transcriptional regulatory protein WalR-like
19	181	Gene3D	G3DSA:3.40.50.300	-
19	181	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
463	821	Gene3D	G3DSA:1.25.40.10	Tetratricopeptide repeat domain
463	821	InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
834	900	SUPERFAMILY	SSF46894	C-terminal effector domain of the bipartite response regulators
834	900	InterPro	IPR016032	Signal transduction response regulator, C-terminal effector
841	897	CDD	cd06170	LuxR_C_like
841	897	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
855	882	ProSitePatterns	PS00622	LuxR-type HTH domain signature.
855	882	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
834	899	ProSiteProfiles	PS50043	LuxR-type HTH domain profile.
834	899	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
466	807	Pfam	PF17874	MalT-like TPR region
466	807	InterPro	IPR041617	MalT-like TPR region
871	883	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
871	883	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
841	855	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
841	855	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
855	871	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
855	871	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
841	895	Pfam	PF00196	Bacterial regulatory proteins, luxR family
841	895	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
32	232	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases
32	232	InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1759	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.359
1				0.267

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
4QT	4ZMS	Q8DNC2	393.8 Da LogP 3.26 TPSA 84.9	✓ Ro5	✓ Clean	`c1(c(c(c(c(c1Br)OO)Br)OO)Br)N`
BEF	4E7P	Q8DNC2	66.0 Da LogP 0.88 TPSA 0.0	✓ Ro5	✓ Clean	`[Be-](F)(F)F`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA1759