Protein profile

PA1766

hypothetical protein

Genome: NC_002516.2

Gene: PA1766 Structure source: AlphaFold UniProt Q9I2X3
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Amino acids 327
Annotations 5
Features 9
PDB binders 0
Druggability 0.74

Overview

Basic information about this protein and its source genome.

Accession
PA1766
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1766
Status
annotated
Amino acids
327
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872 Binding to a metal ion. GO:0018169 Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. GO:0009432 An error-prone process for repairing damaged microbial DNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.74
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MSIWKTWKDLTAKGVMGINRRNADYVLKYNKRHLYPVVDDKIITKERALEAGIHVPEMYGIIETEKGIDKLNEIIGEHNDFVIKPAQGAGGDGIMVIADRFEGRYKTVSGKIVSHEEIEHHISSILSGLYSLGGHRDRVLIEYRVTPDQIFKSISYEGVPDIRIIVLMGYPVMAMLRLPTRQSGGKANLHQGAIGVGVDLATGVTLRGTWLNNKIAKHPDTTNAVDGVQLPNWDGFMKLAAGCYELSGLGYIGVDMVLDQEKGPLILELNARPGLNIQIANDSGLVHRCHAVEARLEELKAKGIEESAEERVRFSQQLFGHVQQHQG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0046872 Binding to a metal ion.
  • GO:0018169 Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6.
  • GO:0009432 An error-prone process for repairing damaged microbial DNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
159 294 Gene3D G3DSA:3.30.470.20 -
45 305 ProSiteProfiles PS50975 ATP-grasp fold profile.
45 305 InterPro IPR011761 ATP-grasp fold
40 279 SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like
4 323 NCBIfam TIGR02291 alpha-L-glutamate ligase-like protein
4 323 InterPro IPR011758 Alpha-L-glutamate ligase-related protein
29 300 PANTHER PTHR21621 RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN
20 293 Pfam PF14397 Sugar-transfer associated ATP-grasp
20 293 InterPro IPR039523 Alpha-L-glutamate ligase-related protein, ATP-grasp domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1766
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.74