Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1775
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cmpX PA1775
Status: annotated
Amino acids: 274
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381 Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.927

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0008381 Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
185	207	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
87	106	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
99	117	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	23	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
70	98	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
226	273	Gene3D	G3DSA:2.30.30.60	-
226	273	InterPro	IPR023408	Mechanosensitive ion channel MscS, beta-domain superfamily
24	49	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
112	272	PANTHER	PTHR30221	SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL
112	272	InterPro	IPR045275	Mechanosensitive ion channel MscS, archaea/bacteria type
21	42	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
160	179	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
15	61	Pfam	PF05552	Conserved TM helix
15	61	InterPro	IPR008910	Conserved TM helix
109	153	Pfam	PF05552	Conserved TM helix
109	153	InterPro	IPR008910	Conserved TM helix
162	179	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
180	184	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
142	161	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118	140	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
186	208	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
184	271	Pfam	PF00924	Mechanosensitive ion channel
184	271	InterPro	IPR006685	Mechanosensitive ion channel MscS
50	69	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
219	272	SUPERFAMILY	SSF50182	Sm-like ribonucleoproteins
219	272	InterPro	IPR010920	LSM domain superfamily
208	274	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
118	141	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
119	223	Gene3D	G3DSA:1.10.287.1260	-
24	118	Gene3D	G3DSA:1.10.287.1260	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1775	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.927
5				0.784
6				0.672
8				0.456

PA1775