Protein profile

PA1777

outer membrane porin F

Genome: NC_002516.2

Gene: PA1777 oprF Structure source: Experimental + AlphaFold UniProt P13794
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Amino acids 350
Annotations 10
Features 35
PDB binders 8
Druggability 0.534

Overview

Basic information about this protein and its source genome.

Accession
PA1777
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1777 oprF
Status
annotated
Amino acids
350
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. GO:0005509 Binding to a calcium ion (Ca2+). GO:0001851 Binding to a C3b product of the complement cascade. GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.534
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0046930 A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
  • GO:0005509 Binding to a calcium ion (Ca2+).
  • GO:0001851 Binding to a C3b product of the complement cascade.
  • GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
  • GO:0044406 The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction.
  • GO:0006811 The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.
  • GO:0008360 Any process that modulates the surface configuration of a cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records
Show feature table
Start End DB Term Name
244 266 InterPro IPR006664 Outer membrane protein, bacterial
239 345 CDD cd07185 OmpA_C-like
239 345 InterPro IPR006665 OmpA-like domain
25 350 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
222 342 PANTHER PTHR30329 STATOR ELEMENT OF FLAGELLAR MOTOR COMPLEX
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
198 232 SUPERFAMILY SSF103647 TSP type-3 repeat
198 232 InterPro IPR028974 TSP type-3 repeat
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
235 345 SUPERFAMILY SSF103088 OmpA-like
235 345 InterPro IPR036737 OmpA-like domain superfamily
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
244 266 PRINTS PR01021 OMPA domain signature
289 305 PRINTS PR01021 OMPA domain signature
289 305 InterPro IPR006664 Outer membrane protein, bacterial
274 289 PRINTS PR01021 OMPA domain signature
274 289 InterPro IPR006664 Outer membrane protein, bacterial
45 188 SUPERFAMILY SSF56925 OMPA-like
45 188 InterPro IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel
14 184 Gene3D G3DSA:2.40.160.20 -
1 188 Pfam PF05736 OprF membrane domain
1 188 InterPro IPR008722 Outer membrane porin F, N-terminal
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
229 347 FunFam G3DSA:3.30.1330.60:FF:000005 Outer membrane porin F
276 321 ProSitePatterns PS01068 OmpA-like domain.
276 321 InterPro IPR006690 Outer membrane protein, OmpA-like, conserved site
229 350 Gene3D G3DSA:3.30.1330.60 -
229 350 InterPro IPR036737 OmpA-like domain superfamily
231 349 ProSiteProfiles PS51123 OmpA-like domain profile.
231 349 InterPro IPR006665 OmpA-like domain
1 26 SignalP_EUK SignalP-noTM SignalP-noTM
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
244 339 Pfam PF00691 OmpA family
244 339 InterPro IPR006665 OmpA-like domain
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4RLC
X-ray 1.60 Å A
45.7% 25-184
PDBe RCSB PDBj File
Viewing
PDB 5U1H
X-ray 1.50 Å A,B,C,D
34.3% 231-350
PDBe RCSB PDBj File
Loaded
AlphaFold PA1777
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
7QA
5U1H 1.50 Å Open crystal
305.3 Da LogP -1.21 TPSA 179.0 1 viol. ✓ Clean C[C@H](C(=O)O)NC(=O)[C@H](CCC[C@H](C(=O)O)N)NC(…
C8E
4RLC 1.60 Å Open crystal
306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.