Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1785
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1785
Status: annotated
Amino acids: 192
Structure source: AlphaFold

GO

GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0090352 Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.905

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0003723 Binding to an RNA molecule or a portion thereof.
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
GO:0090352 Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
134	188	FunFam	G3DSA:1.10.10.10:FF:000299	ANTAR domain-containing response regulator
1	184	SUPERFAMILY	SSF52172	CheY-like
1	184	InterPro	IPR011006	CheY-like superfamily
2	113	SMART	SM00448	REC_2
2	113	InterPro	IPR001789	Signal transduction response regulator, receiver domain
123	184	ProSiteProfiles	PS50921	ANTAR domain profile.
123	184	InterPro	IPR005561	ANTAR domain
129	184	SMART	SM01012	ANTAR_2
129	184	InterPro	IPR005561	ANTAR domain
1	191	PIRSF	PIRSF036382	RR_antiterminator
1	191	InterPro	IPR008327	Signal transduction response regulator, antiterminator
3	117	ProSiteProfiles	PS50110	Response regulatory domain profile.
3	117	InterPro	IPR001789	Signal transduction response regulator, receiver domain
134	184	Pfam	PF03861	ANTAR domain
134	184	InterPro	IPR005561	ANTAR domain
1	130	Gene3D	G3DSA:3.40.50.2300	-
2	122	PANTHER	PTHR43367	-
134	188	Gene3D	G3DSA:1.10.10.10	-
134	188	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
4	110	Pfam	PF00072	Response regulator receiver domain
4	110	InterPro	IPR001789	Signal transduction response regulator, receiver domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1785	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.905
3				0.392

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
AZI	1S8N	P9WGM3	42.0 Da LogP 0.87 TPSA 58.7	✓ Ro5	Alert	`[N-]=[N+]=[N-]`
BEF	4LDZ	O34723	66.0 Da LogP 0.88 TPSA 0.0	✓ Ro5	✓ Clean	`[Be-](F)(F)F`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA1785