Protein profile

PA1800

trigger factor

Genome: NC_002516.2

Gene: PA1800 tig Structure source: AlphaFold UniProt Q9I2U2
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Amino acids 436
Annotations 10
Features 29
PDB binders 0
Druggability 0.775

Overview

Basic information about this protein and its source genome.

Accession
PA1800
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1800 tig
Status
annotated
Amino acids
436
Structure source
AlphaFold
EC
5.2.1.8
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process. GO:0043022 Binding to a ribosome. GO:0051083 The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.775
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
  • GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
  • GO:0043022 Binding to a ribosome.
  • GO:0051083 The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
  • GO:0051301 The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0043335 The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
248 428 SUPERFAMILY SSF109998 Triger factor/SurA peptide-binding domain-like
248 428 InterPro IPR027304 Trigger factor/SurA domain superfamily
161 221 ProSiteProfiles PS50059 FKBP-type peptidyl-prolyl cis-trans isomerase domain profile.
161 221 InterPro IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
1 417 Hamap MF_00303 Trigger factor [tig].
1 417 InterPro IPR005215 Trigger factor
116 416 Gene3D G3DSA:1.10.3120.10 -
116 416 InterPro IPR037041 Trigger factor, C-terminal domain superfamily
150 246 Gene3D G3DSA:3.10.50.40 -
150 246 InterPro IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
1 142 Pfam PF05697 Bacterial trigger factor protein (TF)
1 142 InterPro IPR008881 Trigger factor, ribosome-binding, bacterial
90 241 SUPERFAMILY SSF54534 FKBP-like
152 246 FunFam G3DSA:3.10.50.40:FF:000001 Trigger factor
1 130 SUPERFAMILY SSF102735 Trigger factor ribosome-binding domain
1 130 InterPro IPR036611 Trigger factor ribosome-binding domain superfamily
1 432 PIRSF PIRSF003095 Trigger_factor
1 432 InterPro IPR005215 Trigger factor
1 403 PANTHER PTHR30560 TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE
1 403 InterPro IPR005215 Trigger factor
263 411 Pfam PF05698 Bacterial trigger factor protein (TF) C-terminus
263 411 InterPro IPR008880 Trigger factor, C-terminal
11 410 NCBIfam TIGR00115 trigger factor
11 410 InterPro IPR005215 Trigger factor
1 115 Gene3D G3DSA:3.30.70.1050 -
1 115 InterPro IPR036611 Trigger factor ribosome-binding domain superfamily
1 115 FunFam G3DSA:3.30.70.1050:FF:000001 Trigger factor
156 236 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase
156 236 InterPro IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1800
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.775
2 0.456
1 0.412