Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1804
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1804 hupB
Status: annotated
Amino acids: 90
Structure source: AlphaFold

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990103 A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC. GO:1990178 A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0042802 Binding to an identical protein or proteins. GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.476

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:1990103 A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC.
GO:1990178 A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0042802 Binding to an identical protein or proteins.
GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
GO:0006270 The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
GO:0006351 The synthesis of an RNA transcript from a DNA template.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
46	65	ProSitePatterns	PS00045	Bacterial histone-like DNA-binding proteins signature.
46	65	InterPro	IPR020816	Histone-like DNA-binding protein, conserved site
1	89	PANTHER	PTHR33175	DNA-BINDING PROTEIN HU
1	89	InterPro	IPR000119	Histone-like DNA-binding protein
1	90	Gene3D	G3DSA:4.10.520.10	-
1	90	InterPro	IPR010992	Integration host factor (IHF)-like DNA-binding domain superfamily
2	87	CDD	cd13831	HU
1	90	SMART	SM00411	bhlneu
1	90	InterPro	IPR000119	Histone-like DNA-binding protein
1	90	Pfam	PF00216	Bacterial DNA-binding protein
1	90	SUPERFAMILY	SSF47729	IHF-like DNA-binding proteins
74	88	PRINTS	PR01727	Prokaryotic integration host factor signature
74	88	InterPro	IPR000119	Histone-like DNA-binding protein
40	55	PRINTS	PR01727	Prokaryotic integration host factor signature
40	55	InterPro	IPR000119	Histone-like DNA-binding protein
58	71	PRINTS	PR01727	Prokaryotic integration host factor signature
58	71	InterPro	IPR000119	Histone-like DNA-binding protein
1	90	FunFam	G3DSA:4.10.520.10:FF:000001	DNA-binding protein HU

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1804	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.476

PA1804