Protein profile

PA1816

DNA polymerase III subunit epsilon

Genome: NC_002516.2

Gene: GUL26_19710 L4V69_21620 DT376_08780 IPC1295_05890 CAZ10_25785 GNQ48_00440 dnaQ PA1816 PAERUG_P19_London_7_VIM_2_05_10_06010 Structure source: AlphaFold UniProt Q9L7T4 UniProt G3XD54
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Amino acids 246
Annotations 9
Features 16
PDB binders 0
Druggability 0.566

Overview

Basic information about this protein and its source genome.

Accession
PA1816
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
GUL26_19710 L4V69_21620 DT376_08780 IPC1295_05890 CAZ10_25785 GNQ48_00440 dnaQ PA1816 PAERUG_P19_London_7_VIM_2_05_10_06010
Status
annotated
Amino acids
246
Structure source
AlphaFold
EC
2.7.7.7
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0046872 Binding to a metal ion. GO:0045004 Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.566
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • GO:0046872 Binding to a metal ion.
  • GO:0045004 Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
  • GO:0006260 The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
  • GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 181 FunFam G3DSA:3.30.420.10:FF:000012 DNA polymerase III subunit epsilon
1 183 Gene3D G3DSA:3.30.420.10 -
1 183 InterPro IPR036397 Ribonuclease H superfamily
4 167 Pfam PF00929 Exonuclease
4 167 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
4 171 CDD cd06131 DNA_pol_III_epsilon_Ecoli_like
4 171 InterPro IPR006309 DNA polymerase 3, epsilon subunit
3 194 PANTHER PTHR30231 DNA POLYMERASE III SUBUNIT EPSILON
2 176 SMART SM00479 exoiiiendus
2 176 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
3 178 NCBIfam TIGR00573 exonuclease, DNA polymerase III, epsilon subunit family
3 178 InterPro IPR006054 DNA polymerase III epsilon subunit, exonuclease domain
2 238 NCBIfam TIGR01406 DNA polymerase III subunit epsilon
2 238 InterPro IPR006309 DNA polymerase 3, epsilon subunit
1 177 SUPERFAMILY SSF53098 Ribonuclease H-like
1 177 InterPro IPR012337 Ribonuclease H-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1816
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.566