Protein profile

PA1844

hypothetical protein

Genome: NC_002516.2

Gene: tse1 PA1844 Structure source: Experimental + AlphaFold UniProt Q9I2Q1
Export view
Amino acids 154
Annotations 4
Features 4
PDB binders 0
Druggability 0.615

Overview

Basic information about this protein and its source genome.

Accession
PA1844
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tse1 PA1844
Status
annotated
Amino acids
154
Structure source
Experimental + AlphaFold
EC
3.4.19.11
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0033644 Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. GO:0004040 Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.615
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
  • GO:0033644 Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
  • GO:0004040 Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.

Sequence Features

Domain/signature hits from InterPro and related databases.

4 records
Show feature table
Start End DB Term Name
3 154 Gene3D G3DSA:3.90.1720.10 endopeptidase domain like (from Nostoc punctiforme)
3 154 FunFam G3DSA:3.90.1720.10:FF:000012 Uncharacterized protein
7 100 SUPERFAMILY SSF54001 Cysteine proteinases
7 100 InterPro IPR038765 Papain-like cysteine peptidase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

14 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4F0W
X-ray 1.24 Å A
100.0% 1-154
PDBe RCSB PDBj File
Viewing
PDB 4EQ8
X-ray 1.39 Å A
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 3VPI
X-ray 1.50 Å A
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4F0V
X-ray 1.60 Å A
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4FGE
X-ray 1.70 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 7TVH
X-ray 1.71 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4FQA
X-ray 2.10 Å A
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 3VPJ
X-ray 2.50 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4FGD
X-ray 2.60 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4EOB
X-ray 2.61 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4F4M
X-ray 2.68 Å A,B,C,D
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4FQB
X-ray 2.69 Å A,C,E,G
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4FGI
X-ray 3.20 Å A,C,E,G
100.0% 1-154
PDBe RCSB PDBj File
Loaded
PDB 4EQA
X-ray 1.60 Å A,B
92.9% 6-148
PDBe RCSB PDBj File
Loaded
AlphaFold PA1844
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.615
2 0.248

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.75 0.524