Protein profile

PA1847

Fe/S biogenesis protein NfuA

Genome: NC_002516.2

Gene: nfuA PA1847 Structure source: AlphaFold UniProt Q9I2P8
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Amino acids 194
Annotations 5
Features 17
PDB binders 0
Druggability 0.817

Overview

Basic information about this protein and its source genome.

Accession
PA1847
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nfuA PA1847
Status
annotated
Amino acids
194
Structure source
AlphaFold
GO
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506 Binding to an iron (Fe) ion. GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0051604 Any process leading to the attainment of the full functional capacity of a protein. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
35.526
Human E-value
3.69e-06
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.817
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0051604 Any process leading to the attainment of the full functional capacity of a protein.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
114 180 Pfam PF01106 NifU-like domain
114 180 InterPro IPR001075 NIF system FeS cluster assembly, NifU, C-terminal
4 194 NCBIfam TIGR03341 Fe-S biogenesis protein NfuA
4 194 InterPro IPR017726 Fe/S biogenesis protein NfuA
4 100 Pfam PF01521 Iron-sulphur cluster biosynthesis
4 100 InterPro IPR000361 FeS cluster biogenesis
98 188 SUPERFAMILY SSF117916 Fe-S cluster assembly (FSCA) domain-like
98 188 InterPro IPR034904 Fe-S cluster assembly domain superfamily
1 103 Gene3D G3DSA:2.60.300.12 -
1 103 InterPro IPR035903 HesB-like domain superfamily
99 188 PANTHER PTHR11178 IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED
104 192 Gene3D G3DSA:3.30.300.130 -
104 192 InterPro IPR034904 Fe-S cluster assembly domain superfamily
3 100 SUPERFAMILY SSF89360 HesB-like domain
3 100 InterPro IPR035903 HesB-like domain superfamily
3 194 Hamap MF_01637 Fe/S biogenesis protein NfuA [nfuA].
3 194 InterPro IPR017726 Fe/S biogenesis protein NfuA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1847
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.817
2 0.512