Amino acids
2468
Annotations
2
Features
123
PDB binders
0
Druggability
0.772
Overview
Basic information about this protein and its source genome.
- Accession
- PA1874
- Gene
- PA1874
- Status
- annotated
- Amino acids
- 2468
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Unknown
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.772
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
2 GO
Gene Ontology (GO)
2- GO:0001681 Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.
- GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
Sequence Features
Domain/signature hits from InterPro and related databases.
123 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 509 | 547 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 20 | 72 | NCBIfam | NF033677 | BapA prefix-like domain |
| 2271 | 2459 | SUPERFAMILY | SSF51120 | beta-Roll |
| 2271 | 2459 | InterPro | IPR011049 | Serralysin-like metalloprotease, C-terminal |
| 925 | 1136 | PANTHER | PTHR22901 | SIALATE O-ACETYLESTERASE |
| 925 | 1136 | InterPro | IPR039329 | Sialate O-acetylesterase |
| 1893 | 1971 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 989 | 1067 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1810 | 1887 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1740 | 1805 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 661 | 739 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1659 | 1723 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1565 | 1641 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 838 | 903 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1084 | 1149 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1319 | 1395 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 908 | 985 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1473 | 1559 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 178 | 240 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 499 | 575 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 744 | 821 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 581 | 657 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 427 | 493 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1247 | 1313 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1154 | 1231 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 247 | 326 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 331 | 412 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 1409 | 1470 | NCBIfam | NF033510 | Ca2+-stabilized adhesin repeat |
| 235 | 291 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 568 | 660 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 667 | 741 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 667 | 741 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1897 | 1973 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1897 | 1973 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1077 | 1152 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1077 | 1152 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 333 | 416 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 333 | 416 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 831 | 905 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 831 | 905 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1323 | 1397 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1323 | 1397 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 164 | 243 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 164 | 243 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 585 | 660 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 585 | 660 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1815 | 1889 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1815 | 1889 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1733 | 1807 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1733 | 1807 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1241 | 1315 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1241 | 1315 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 420 | 496 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 420 | 496 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1651 | 1726 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1651 | 1726 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1487 | 1561 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1487 | 1561 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1569 | 1644 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1569 | 1644 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1159 | 1234 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1159 | 1234 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 246 | 331 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 246 | 331 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 913 | 988 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 913 | 988 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 995 | 1069 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 995 | 1069 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 503 | 578 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 503 | 578 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 749 | 823 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 749 | 823 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 1398 | 1479 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins |
| 1398 | 1479 | InterPro | IPR013783 | Immunoglobulin-like fold |
| 591 | 660 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 512 | 547 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 153 | 197 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 1307 | 1368 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 235 | 253 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 1652 | 1730 | Pfam | PF17936 | Bacterial Ig domain |
| 1652 | 1730 | InterPro | IPR041498 | Bacterial Ig domain |
| 1415 | 1484 | Pfam | PF17936 | Bacterial Ig domain |
| 1415 | 1484 | InterPro | IPR041498 | Bacterial Ig domain |
| 750 | 828 | Pfam | PF17936 | Bacterial Ig domain |
| 750 | 828 | InterPro | IPR041498 | Bacterial Ig domain |
| 1160 | 1238 | Pfam | PF17936 | Bacterial Ig domain |
| 1160 | 1238 | InterPro | IPR041498 | Bacterial Ig domain |
| 1488 | 1566 | Pfam | PF17936 | Bacterial Ig domain |
| 1488 | 1566 | InterPro | IPR041498 | Bacterial Ig domain |
| 1816 | 1894 | Pfam | PF17936 | Bacterial Ig domain |
| 1816 | 1894 | InterPro | IPR041498 | Bacterial Ig domain |
| 1570 | 1648 | Pfam | PF17936 | Bacterial Ig domain |
| 1570 | 1648 | InterPro | IPR041498 | Bacterial Ig domain |
| 832 | 910 | Pfam | PF17936 | Bacterial Ig domain |
| 832 | 910 | InterPro | IPR041498 | Bacterial Ig domain |
| 167 | 249 | Pfam | PF17936 | Bacterial Ig domain |
| 167 | 249 | InterPro | IPR041498 | Bacterial Ig domain |
| 1078 | 1156 | Pfam | PF17936 | Bacterial Ig domain |
| 1078 | 1156 | InterPro | IPR041498 | Bacterial Ig domain |
| 423 | 500 | Pfam | PF17936 | Bacterial Ig domain |
| 423 | 500 | InterPro | IPR041498 | Bacterial Ig domain |
| 1734 | 1812 | Pfam | PF17936 | Bacterial Ig domain |
| 1734 | 1812 | InterPro | IPR041498 | Bacterial Ig domain |
| 586 | 664 | Pfam | PF17936 | Bacterial Ig domain |
| 586 | 664 | InterPro | IPR041498 | Bacterial Ig domain |
| 996 | 1074 | Pfam | PF17936 | Bacterial Ig domain |
| 996 | 1074 | InterPro | IPR041498 | Bacterial Ig domain |
| 504 | 582 | Pfam | PF17936 | Bacterial Ig domain |
| 504 | 582 | InterPro | IPR041498 | Bacterial Ig domain |
| 668 | 746 | Pfam | PF17936 | Bacterial Ig domain |
| 668 | 746 | InterPro | IPR041498 | Bacterial Ig domain |
| 338 | 421 | Pfam | PF17936 | Bacterial Ig domain |
| 338 | 421 | InterPro | IPR041498 | Bacterial Ig domain |
| 914 | 992 | Pfam | PF17936 | Bacterial Ig domain |
| 914 | 992 | InterPro | IPR041498 | Bacterial Ig domain |
| 1242 | 1320 | Pfam | PF17936 | Bacterial Ig domain |
| 1242 | 1320 | InterPro | IPR041498 | Bacterial Ig domain |
| 1324 | 1402 | Pfam | PF17936 | Bacterial Ig domain |
| 1324 | 1402 | InterPro | IPR041498 | Bacterial Ig domain |
| 252 | 335 | Pfam | PF17936 | Bacterial Ig domain |
| 252 | 335 | InterPro | IPR041498 | Bacterial Ig domain |
| 1898 | 1980 | Pfam | PF17936 | Bacterial Ig domain |
| 1898 | 1980 | InterPro | IPR041498 | Bacterial Ig domain |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA1874
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 9 | 0.772 | ||||||
| 5 | 0.567 | ||||||
| 7 | 0.318 |