Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1875
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1875
Status: annotated
Amino acids: 425
Structure source: AlphaFold

GO

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO:0015288 Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
17	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
29	412	FunFam	G3DSA:1.20.1600.10:FF:000016	Outer membrane protein
378	398	Coils	Coil	Coil
1	17	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
29	412	Gene3D	G3DSA:1.20.1600.10	Outer membrane efflux proteins (OEP)
18	418	PANTHER	PTHR30026	OUTER MEMBRANE PROTEIN TOLC
244	264	Coils	Coil	Coil
18	29	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	32	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	41	Phobius	SIGNAL_PEPTIDE	Signal peptide region
42	425	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
245	401	Pfam	PF02321	Outer membrane efflux protein
245	401	InterPro	IPR003423	Outer membrane efflux protein
35	211	Pfam	PF02321	Outer membrane efflux protein
35	211	InterPro	IPR003423	Outer membrane efflux protein
15	413	SUPERFAMILY	SSF56954	Outer membrane efflux proteins (OEP)
1	32	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
178	205	Coils	Coil	Coil
30	41	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1875	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.405
2				0.248
6				0.244

PA1875