Protein profile

PA1877

secretion protein

Genome: NC_002516.2

Gene: PA1877 Structure source: AlphaFold UniProt Q9I2M0
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Amino acids 395
Annotations 1
Features 17
PDB binders 0
Druggability 0.51

Overview

Basic information about this protein and its source genome.

Accession
PA1877
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1877
Status
annotated
Amino acids
395
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.51
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 28 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
258 382 Gene3D G3DSA:2.40.30.170 -
67 131 Gene3D G3DSA:2.40.50.100 -
67 109 Pfam PF13533 Biotin-lipoyl like
67 109 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
50 395 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
249 356 Pfam PF13437 HlyD family secretion protein
25 47 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
31 391 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
379 395 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
34 57 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
294 318 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
76 96 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
364 379 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
318 341 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
261 282 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1877
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.51
6 0.491
13 0.288
14 0.256