Protein profile

PA1887

hypothetical protein

Genome: NC_002516.2

Gene: PA1887 Structure source: AlphaFold UniProt Q9I2L0
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Amino acids 222
Annotations 3
Features 9
PDB binders 0
Druggability 0.945

Overview

Basic information about this protein and its source genome.

Accession
PA1887
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1887
Status
annotated
Amino acids
222
Structure source
AlphaFold
GO
GO:0004623 A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. GO:0050482 The controlled release of arachidonic acid from a cell or a tissue. GO:0006644 The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004623 A glycerophospholipase activity that cleaves the fatty acid attached to the sn-2 position of the glycerol group of a glycerophospholipid. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
  • GO:0050482 The controlled release of arachidonic acid from a cell or a tissue.
  • GO:0006644 The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 27 Phobius SIGNAL_PEPTIDE Signal peptide region
19 27 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 27 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 222 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 129 Gene3D G3DSA:1.20.90.10 Phospholipase A2 domain
18 129 InterPro IPR036444 Phospholipase A2 domain superfamily
1 27 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1887
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.457