Protein profile

PA1899

phenazine biosynthesis protein PhzA

Genome: NC_002516.2

Gene: PA1899 phzA2 Structure source: AlphaFold UniProt Q9I2J9

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Amino acids 162

Annotations 2

Features 6

PDB binders 0

Druggability 0.818

Overview

Basic information about this protein and its source genome.

Accession: PA1899
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1899 phzA2
Status: annotated
Amino acids: 162
Structure source: AlphaFold

GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.818

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records

Show feature table

Start	End	DB	Term	Name
20	149	SUPERFAMILY	SSF54427	NTF2-like
20	149	InterPro	IPR032710	NTF2-like domain superfamily
12	152	FunFam	G3DSA:3.10.450.50:FF:000014	Phenazine biosynthesis protein PhzB 2
12	152	Gene3D	G3DSA:3.10.450.50	-
1	162	Pfam	PF03284	Phenazine biosynthesis protein A/B
1	162	InterPro	IPR004964	Phenazine biosynthesis protein A/B

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1899	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.818