Protein profile

PA1900

phenazine biosynthesis protein PhzB

Genome: NC_002516.2

Gene: PA1900 phzB2 Structure source: Experimental + AlphaFold UniProt Q9S508
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Amino acids 162
Annotations 2
Features 6
PDB binders 0
Druggability 0.752

Overview

Basic information about this protein and its source genome.

Accession
PA1900
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1900 phzB2
Status
annotated
Amino acids
162
Structure source
Experimental + AlphaFold
GO
GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.752
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MLDNAIPQGFEDAVELRRKNRETVVKYMNTKGQDRLRRHELFVEDGCGGLWTTDTGSPIVIRGKDKLAEHAVWSLKCFPDWEWYNIKVFETDDPNHFWVECDGHGKILFPGYPEGYYENHFLHSFELDDGKIKRNREFMNVFQQLRALSIPVPQIKREGIPT

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0002047 The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
  • GO:0017000 The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
1 162 Pfam PF03284 Phenazine biosynthesis protein A/B
1 162 InterPro IPR004964 Phenazine biosynthesis protein A/B
12 152 Gene3D G3DSA:3.10.450.50 -
19 148 SUPERFAMILY SSF54427 NTF2-like
19 148 InterPro IPR032710 NTF2-like domain superfamily
12 152 FunFam G3DSA:3.10.450.50:FF:000014 Phenazine biosynthesis protein PhzB 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3FF0
X-ray 1.90 Å A,B
100.0% 1-162
PDBe RCSB PDBj File
Viewing
AlphaFold PA1900
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.752

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 42.16 0.967