Protein profile

PA1910

ferric-mycobactin receptor FemA

Genome: NC_002516.2

Gene: femA PA1910 Structure source: Experimental + AlphaFold UniProt Q9I2J4
Export view
Amino acids 804
Annotations 10
Features 31
PDB binders 6
Druggability 0.88

Overview

Basic information about this protein and its source genome.

Accession
PA1910
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
femA PA1910
Status
annotated
Amino acids
804
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0016987 Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.88
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
  • GO:0016987 Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.
  • GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
  • GO:0034756 Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0033214 A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores is imported into the cell by transmembrane transport or endocytosis.
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0015343 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
383 801 Pfam PF00593 TonB dependent receptor
383 801 InterPro IPR000531 TonB-dependent receptor-like, beta-barrel
34 804 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
26 33 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
110 804 PANTHER PTHR32552 FERRICHROME IRON RECEPTOR-RELATED
110 804 InterPro IPR039426 TonB-dependent receptor-like
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
36 136 FunFam G3DSA:3.55.50.30:FF:000002 Probable TonB-dependent receptor
157 804 SUPERFAMILY SSF56935 Porins
168 804 CDD cd01347 ligand_gated_channel
787 804 ProSitePatterns PS01156 TonB-dependent receptor proteins signature 2.
787 804 InterPro IPR010917 TonB-dependent receptor, conserved site
10 25 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
162 260 Pfam PF07715 TonB-dependent Receptor Plug Domain
162 260 InterPro IPR012910 TonB-dependent receptor, plug domain
275 804 Gene3D G3DSA:2.40.170.20 -
275 804 InterPro IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily
156 274 Gene3D G3DSA:2.170.130.10 -
156 274 InterPro IPR037066 TonB-dependent receptor, plug domain superfamily
65 116 SMART SM00965 STN_2
65 116 InterPro IPR011662 Secretin/TonB, short N-terminal domain
1 33 Phobius SIGNAL_PEPTIDE Signal peptide region
65 115 Pfam PF07660 Secretin and TonB N terminus short domain
65 115 InterPro IPR011662 Secretin/TonB, short N-terminal domain
164 804 NCBIfam TIGR01783 TonB-dependent siderophore receptor
164 804 InterPro IPR010105 TonB-dependent siderophore receptor
1 33 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
36 138 Gene3D G3DSA:3.55.50.30 -
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 33 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 9EX3
X-ray 2.15 Å A,B
96.5% 29-804
PDBe RCSB PDBj File
Viewing
PDB 9F2T
X-ray 2.20 Å A,B
96.5% 29-804
PDBe RCSB PDBj File
Loaded
PDB 8S34
X-ray 1.86 Å A,B
96.5% 29-804
PDBe RCSB PDBj File
Metadata only
PDB 9FVQ
X-ray 2.03 Å A,B
83.3% 135-804
PDBe RCSB PDBj File
Metadata only
AlphaFold PA1910
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

56 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
6L0
6Z8A
Q9I116 598.7 Da LogP 0.63 TPSA 208.9 2 viol. ✓ Clean C1CCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(C/C=C/CC…
C8E
5FP1
D0CAH3 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
FTT
6I98
Q9I116 244.4 Da LogP 3.74 TPSA 57.5 ✓ Ro5 ✓ Clean CCCCCCCCCCC[C@H](CC(=O)O)O
FV8
6H7F
Q76HJ9 346.3 Da LogP 0.82 TPSA 131.3 ✓ Ro5 Alert C[C@@H]1[C@H](N=C(O1)c2cccc(c2O)O)C(=O)N(CCc3c[…
OPV
6H7F
Q76HJ9 346.3 Da LogP 0.32 TPSA 127.8 ✓ Ro5 Alert C[C@H]1[C@@H](C(=O)N(O1)CCc2c[nH]cn2)NC(=O)c3cc…
OPZ
6H7F
Q76HJ9 346.3 Da LogP 0.32 TPSA 127.8 ✓ Ro5 Alert C[C@@H]1[C@@H](C(=O)N(O1)CCc2c[nH]cn2)NC(=O)c3c…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.