Protein profile

PA1915

hypothetical protein

Genome: NC_002516.2

Gene: PA1915 Structure source: AlphaFold UniProt Q9I2I9
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Amino acids 515
Annotations 2
Features 8
PDB binders 0
Druggability 0.693

Overview

Basic information about this protein and its source genome.

Accession
PA1915
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1915
Status
annotated
Amino acids
515
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.693
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPQSIRHLIALPELRSRLLSGAGGLDRPVRWAHVCELDDPTEWLGEGDLLMTTGLGIPSDAERQRRYVRRLAEAGLAGMMIGENMEAPSDLDALRETAEALGFPLILTHYGVPFAAVTRAIVDAGQKDEYERRNALARIYESARLSMQGLGLPALLQRLGKDVRSSLYLIVPDTLAAWQPGLPGLPVELADALRNRRREQAEPQPMVLRHPLAEGEALSIGIPSDRNCLLIALGERLPDYSLLHHLTAVLGIEIERLRVESERHLRLGSELLDDLLQRRLYREQAEERLEELLPGLDLDDAVVSVASSEGLATDPFGLFRGHDSRLLVRAQGQEIILLHQAGLASTLQEALDSSLGVSAPLRRAERCAEALREARLALAHSHSRRPLCRYAELDDEAPWLPRSLAEAERAFRLVLGALHDYDAANGSALLHTLQVFLEENRSWLNAAQRLHIHKQSLVYRIRRIEEISGRSLDSTADVATLWFALQATRLSPEARGRTAKGSLLEQSAHHGGDMD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
429 487 Pfam PF13556 PucR C-terminal helix-turn-helix domain
429 487 InterPro IPR025736 PucR C-terminal helix-turn-helix domain
1 495 PANTHER PTHR33744 CARBOHYDRATE DIACID REGULATOR
363 491 Gene3D G3DSA:1.10.10.2840 -
363 491 InterPro IPR042070 PucR C-terminal helix-turn-helix domain superfamily
8 123 Pfam PF07905 Purine catabolism regulatory protein-like family
8 123 InterPro IPR012914 Purine catabolism PurC-like domain
496 515 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1915
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.693
2 0.248