Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA1960
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA1960
Status: annotated
Amino acids: 240
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003730 Binding to a 3' untranslated region of an mRNA molecule. GO:0043488 Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. GO:0003676 Binding to a nucleic acid.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.814

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0003730 Binding to a 3' untranslated region of an mRNA molecule.
GO:0043488 Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
GO:0003676 Binding to a nucleic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records

Show feature table

Start	End	DB	Term	Name
18	79	CDD	cd04458	CSP_CDS
18	79	InterPro	IPR002059	Cold-shock protein, DNA-binding
15	79	ProSiteProfiles	PS51857	Cold-shock (CSD) domain profile.
15	79	InterPro	IPR002059	Cold-shock protein, DNA-binding
224	240	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
119	138	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
143	161	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
119	137	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	78	SUPERFAMILY	SSF50249	Nucleic acid-binding proteins
10	78	InterPro	IPR012340	Nucleic acid-binding, OB-fold
205	222	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
2	86	FunFam	G3DSA:2.40.50.140:FF:000501	Cold shock protein
22	73	Pfam	PF00313	'Cold-shock' DNA-binding domain
22	73	InterPro	IPR002059	Cold-shock protein, DNA-binding
1	118	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
205	223	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
5	89	PANTHER	PTHR12962	CALCIUM-REGULATED HEAT STABLE PROTEIN CRHSP-24-RELATED
153	207	Pfam	PF06961	Protein of unknown function (DUF1294)
153	207	InterPro	IPR010718	Protein of unknown function DUF1294
29	48	ProSitePatterns	PS00352	Cold-shock (CSD) domain signature.
29	48	InterPro	IPR019844	Cold-shock (CSD) domain
142	161	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
162	204	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
138	142	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2	86	Gene3D	G3DSA:2.40.50.140	-
2	86	InterPro	IPR012340	Nucleic acid-binding, OB-fold

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA1960	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.814
2				0.786
5				0.304

PA1960