Protein profile

PA1966

hypothetical protein

Genome: NC_002516.2

Gene: PA1966 Structure source: Experimental + AlphaFold UniProt Q9I2D8
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Amino acids 123
Annotations 2
Features 10
PDB binders 0
Druggability 0.847

Overview

Basic information about this protein and its source genome.

Accession
PA1966
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1966
Status
annotated
Amino acids
123
Structure source
Experimental + AlphaFold
GO
GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.847
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.
  • GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
2 113 CDD cd00580 CHMI
2 113 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase
2 117 Pfam PF02962 5-carboxymethyl-2-hydroxymuconate isomerase
2 117 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase
1 123 Gene3D G3DSA:3.30.429.10 Macrophage Migration Inhibitory Factor
1 123 InterPro IPR014347 Tautomerase/MIF superfamily
2 122 SUPERFAMILY SSF55331 Tautomerase/MIF
2 122 InterPro IPR014347 Tautomerase/MIF superfamily
1 122 PANTHER PTHR37950 4-HYDROXYPHENYLACETATE CATABOLISM PROTEIN
1 122 InterPro IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3E6Q
X-ray 1.75 Å A,B,C,D,E,F,G,H,I,J,K,L
100.0% 1-123
PDBe RCSB PDBj File
Viewing
PDB 4NWP
X-ray 2.10 Å E,F,G,H
100.0% 1-123
PDBe RCSB PDBj File
Loaded
PDB 4NWQ
X-ray 2.80 Å B
100.0% 1-123
PDBe RCSB PDBj File
Loaded
AlphaFold PA1966
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.847
3 0.505