Protein profile

PA1988

coenzyme PQQ synthesis protein D

Genome: NC_002516.2

Gene: PA1988 pqqD Structure source: AlphaFold UniProt Q9I2C1
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Amino acids 92
Annotations 2
Features 8
PDB binders 0
Druggability 0.545

Overview

Basic information about this protein and its source genome.

Accession
PA1988
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA1988 pqqD
Status
annotated
Amino acids
92
Structure source
AlphaFold
GO
GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0018189 The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.545
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0048038 Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
  • GO:0018189 The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 91 Gene3D G3DSA:1.10.10.1150 Coenzyme PQQ synthesis protein D (PqqD)
1 91 InterPro IPR041881 Coenzyme PQQ synthesis protein D superfamily
26 89 Pfam PF05402 Coenzyme PQQ synthesis protein D (PqqD)
26 89 InterPro IPR008792 Coenzyme PQQ synthesis protein D
4 91 Hamap MF_00655 PqqA binding protein [pqqD].
4 91 InterPro IPR022479 Coenzyme PQQ synthesis D, bacteria
10 90 NCBIfam TIGR03859 pyrroloquinoline quinone biosynthesis peptide chaperone PqqD
10 90 InterPro IPR022479 Coenzyme PQQ synthesis D, bacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA1988
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.545