Protein profile

PA2000

dehydrocarnitine CoA transferase subunit B

Genome: NC_002516.2

Gene: PA2000 dhcB Structure source: AlphaFold UniProt Q9I2A9
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Amino acids 218
Annotations 5
Features 14
PDB binders 0
Druggability 0.92

Overview

Basic information about this protein and its source genome.

Accession
PA2000
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2000 dhcB
Status
annotated
Amino acids
218
Structure source
AlphaFold
EC
2.8.3.6
GO
GO:0047569 Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. GO:0042952 A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. GO:0042413 The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
50.235
Human E-value
2.86e-69
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.92
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0047569 Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA.
  • GO:0042952 A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
  • GO:0042413 The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
  • GO:0008410 Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 213 Gene3D G3DSA:3.40.1080.10 -
4 208 NCBIfam TIGR02428 3-oxoacid CoA-transferase subunit B
4 208 InterPro IPR012791 3-oxoacid CoA-transferase, subunit B
2 214 FunFam G3DSA:3.40.1080.10:FF:000001 Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b
4 216 SUPERFAMILY SSF100950 NagB/RpiA/CoA transferase-like
4 216 InterPro IPR037171 NagB/RpiA transferase-like
6 202 SMART SM00882 CoA_trans_3
6 202 InterPro IPR004165 Coenzyme A transferase family I
4 216 PANTHER PTHR13707 KETOACID-COENZYME A TRANSFERASE
4 216 InterPro IPR004165 Coenzyme A transferase family I
44 52 ProSitePatterns PS01274 Coenzyme A transferases signature 2.
44 52 InterPro IPR004164 Coenzyme A transferase active site
6 201 Pfam PF01144 Coenzyme A transferase
6 201 InterPro IPR004165 Coenzyme A transferase family I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2000
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.92
1 0.583