Protein profile

PA2020

transcriptional regulator

Genome: NC_002516.2

Gene: PA2020 L4V69_20565 IPC1295_28305 PAERUG_P19_London_7_VIM_2_05_10_04885 ALP65_02110 ttgR CAZ10_35075 amrR Structure source: Experimental + AlphaFold UniProt G3XCU9 UniProt Q9RG61
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Amino acids 210
Annotations 8
Features 16
PDB binders 0
Druggability 0.894

Overview

Basic information about this protein and its source genome.

Accession
PA2020
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2020 L4V69_20565 IPC1295_28305 PAERUG_P19_London_7_VIM_2_05_10_04885 ALP65_02110 ttgR CAZ10_35075 amrR
Status
annotated
Amino acids
210
Structure source
Experimental + AlphaFold
GO
GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0034763 Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.894
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0032993 A macromolecular complex containing both protein and DNA molecules.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0034763 Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
37 60 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
37 60 InterPro IPR001647 DNA-binding HTH domain, TetR-type
16 29 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
16 29 InterPro IPR001647 DNA-binding HTH domain, TetR-type
16 61 Pfam PF00440 Bacterial regulatory proteins, tetR family
16 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
82 198 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
82 198 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
1 210 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
1 70 SUPERFAMILY SSF46689 Homeodomain-like
1 70 InterPro IPR009057 Homeobox-like domain superfamily
10 70 ProSiteProfiles PS50977 TetR-type HTH domain profile.
10 70 InterPro IPR001647 DNA-binding HTH domain, TetR-type
93 171 Pfam PF08361 MAATS-type transcriptional repressor, C-terminal region
93 171 InterPro IPR013572 Transcription regulator MAATS, C-terminal
2 199 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2WUI
X-ray 2.90 Å A
100.0% 1-210
PDBe RCSB PDBj File
Viewing
AlphaFold PA2020
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.894

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.1 0.918
2 11.67 0.62