Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2033
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2033
Status: annotated
Amino acids: 302
Structure source: AlphaFold

GO

GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0052851 Catalysis of the reaction: 2 a Fe(II)-siderophore + NADP+ + H+ = 2 a Fe(III)-siderophore + NADPH. GO:0010106 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. GO:0033212 The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.668

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MSQPAYRLFNVELKRREQLSPALTRFVFGGPEVAEMKTLAADQRIKIFFPDASGQPPSLPGGSEWYQAYRSVEPARRPPMRTYTIRALRAEQEEVDVEFVLHGENGPASAWATHARIGDRLQLAAPNRQYGDDPGGYEWKPPAGVRHILLIADETALPAVAGILEELAGETEPPVVEAFLEVPGEADILDLPAIPAARLHWLPRHQAGIHSRNGERMIEAARQARLPEREVAGGAAQELEDIDIDEEILWELASPESGSFYAWVAGESAAVMAIRRYLVQERGIDKRHLTLMGYWRLGKVFD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0071949 Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
GO:0052851 Catalysis of the reaction: 2 a Fe(II)-siderophore + NADP+ + H+ = 2 a Fe(III)-siderophore + NADPH.
GO:0010106 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions.
GO:0033212 The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.
GO:0015891 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
13	296	CDD	cd06193	siderophore_interacting
1	129	Gene3D	G3DSA:2.40.30.10	Translation factors
6	128	SUPERFAMILY	SSF63380	Riboflavin synthase domain-like
6	128	InterPro	IPR017938	Riboflavin synthase-like beta-barrel
3	300	PANTHER	PTHR30157	FERRIC REDUCTASE, NADPH-DEPENDENT
3	300	InterPro	IPR039374	Siderophore-interacting protein
143	301	Gene3D	G3DSA:3.40.50.80	-
143	301	InterPro	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
146	298	Pfam	PF04954	Siderophore-interacting protein
146	298	InterPro	IPR007037	Siderophore-interacting protein, C-terminal domain
13	129	Pfam	PF08021	Siderophore-interacting FAD-binding domain
13	129	InterPro	IPR013113	FAD-binding 9, siderophore-interacting
6	133	ProSiteProfiles	PS51384	Ferredoxin reductase-type FAD binding domain profile.
6	133	InterPro	IPR017927	FAD-binding domain, ferredoxin reductase-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2033	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.668

PA2033