Protein profile
PA2045
membrane protein insertion efficiency factor
Genome: NC_002516.2
Overview
Basic information about this protein and its source genome.
- Accession
- PA2045
- Gene
- PA2045
- Status
- annotated
- Amino acids
- 86
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Unknown
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
3- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
- GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 3 | 68 | Pfam | PF01809 | Putative membrane protein insertion efficiency factor |
| 3 | 68 | InterPro | IPR002696 | Membrane protein insertion efficiency factor YidD-like |
| 1 | 69 | Hamap | MF_00386 | Putative membrane protein insertion efficiency factor [yidD]. |
| 1 | 69 | InterPro | IPR002696 | Membrane protein insertion efficiency factor YidD-like |
| 1 | 68 | SMART | SM01234 | Haemolytic_2 |
| 1 | 68 | InterPro | IPR002696 | Membrane protein insertion efficiency factor YidD-like |
| 3 | 65 | NCBIfam | TIGR00278 | membrane protein insertion efficiency factor YidD |
| 3 | 65 | InterPro | IPR002696 | Membrane protein insertion efficiency factor YidD-like |
| 12 | 15 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 16 | 86 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 4 | 74 | PANTHER | PTHR33383 | MEMBRANE PROTEIN INSERTION EFFICIENCY FACTOR-RELATED |
| 4 | 74 | InterPro | IPR002696 | Membrane protein insertion efficiency factor YidD-like |
| 3 | 11 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 1 | 15 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 1 | 2 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA2045
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.766 |