Protein profile

PA2064

copper resistance protein B

Genome: NC_002516.2

Gene: pcoB PA2064 Structure source: AlphaFold UniProt Q9I251
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Amino acids 325
Annotations 3
Features 11
PDB binders 0
Druggability 0.443

Overview

Basic information about this protein and its source genome.

Accession
PA2064
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
pcoB PA2064
Status
annotated
Amino acids
325
Structure source
AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005507 Binding to a copper (Cu) ion. GO:0006878 A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.443
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0005507 Binding to a copper (Cu) ion.
  • GO:0006878 A homeostatic process involved in the maintenance of a steady state level of copper ions within a cell.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 29 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
30 94 MobiDBLite mobidb-lite consensus disorder prediction
1 29 SignalP_EUK SignalP-noTM SignalP-noTM
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
22 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 9 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
10 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
30 325 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
121 325 Pfam PF05275 Copper resistance protein B precursor (CopB)
121 325 InterPro IPR007939 Copper resistance B precursor
169 297 SUPERFAMILY SSF56935 Porins

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2064
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.443