Protein profile

PA2073

transporter membrane subunit

Genome: NC_002516.2

Gene: PA2073 Structure source: AlphaFold UniProt Q9I242
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Amino acids 476
Annotations 4
Features 46
PDB binders 0
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
PA2073
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2073
Status
annotated
Amino acids
476
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

46 records
Show feature table
Start End DB Term Name
428 451 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 440 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin
19 440 InterPro IPR001248 Purine-cytosine permease
264 282 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 465 PIRSF PIRSF002744 Pur-cyt_permease
1 465 InterPro IPR026030 Purine-cytosine permease Fcy2/21/22
283 304 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 452 Gene3D G3DSA:1.10.4160.10 Hydantoin permease
379 402 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
423 427 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
53 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
324 346 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
4 452 PANTHER PTHR31806 PURINE-CYTOSINE PERMEASE FCY2-RELATED
4 452 InterPro IPR026030 Purine-cytosine permease Fcy2/21/22
99 121 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
356 378 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
80 98 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 452 FunFam G3DSA:1.10.4160.10:FF:000016 Purine-cytosine related permease
33 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
346 356 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
305 323 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
33 55 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
122 140 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
167 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
282 304 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 82 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
324 345 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
58 79 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
161 166 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
187 197 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
240 262 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
240 263 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
141 160 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 159 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
198 220 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
221 239 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
198 220 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
403 422 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
166 183 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
452 476 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 455 CDD cd11484 SLC-NCS1sbd_CobB-like
357 378 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
430 452 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
398 420 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2073
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.839
4 0.426
1 0.38