Protein profile

PA2077

hypothetical protein

Genome: NC_002516.2

Gene: PA2077 Structure source: AlphaFold UniProt Q9I238
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Amino acids 634
Annotations 5
Features 16
PDB binders 0
Druggability 0.669

Overview

Basic information about this protein and its source genome.

Accession
PA2077
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2077
Status
annotated
Amino acids
634
Structure source
AlphaFold
GO
GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0031408 The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.669
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTLSRLSLAILSVLAGAPAFADDSGVDLDQGWNQTQKTAWLEAGQGSRMLPLAWLVALEQRASEEPLMSDALIRQYGYVPHTLGGSSVKVVQGYAVDRSDDSDLTFTKLRWKALQGSREPWVGPTCSMCHTSHISYQGTQLTVYGGQTMGDLAGFQLEILGALQSTRADTAKFERFARKVLGADGLVSGYNDANKARLQAALDATIVRLRDGSHFNLPHDPEFGPGRLDAIGSIFNSVGYELHADEQIYGAEDAPVSYPFLWNVPQLDRVQWTGFNPNHINVVDIDNRKFDVGALARNAGEAVGVFADVKVLSPIQSALHIGYPSSINVDNLIRIEDQLGQLKPPAWPNQLFGAPEPTRVAEGRELYRQHCSSCHTPLDRNDLRTPVKTVLTHLQARGEVAPIGTDPWTACNSIAQLKTGYVRGKPYLSFVGTGQRGFYGKQAYAVDVLQEVVVQALAARGLSVALGAFQTAALGIFDGQLPPLISPVPDSPDADSAEATAADAPGALLLAENVAADSDKARRLEQCLAMTSDLMAYKARPLNGIWASPPYLHNGSVATLYDLLLPPDLRPRTFYTGSVEFDPVNVGYITDAGGANRFLFDSGKPGNANGGHDYGNAQFNEQQRRALVEYMKTL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
  • GO:0051213 Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0031408 The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
354 634 SUPERFAMILY SSF46626 Cytochrome c
354 634 InterPro IPR036909 Cytochrome c-like domain superfamily
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
355 421 SUPERFAMILY SSF46626 Cytochrome c
355 421 InterPro IPR036909 Cytochrome c-like domain superfamily
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
32 633 NCBIfam NF040606 di-heme-cytochrome C peroxidase
32 633 InterPro IPR047758 Di-heme-cytochrome C peroxidase
22 634 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 634 PANTHER PTHR30600 CYTOCHROME C PEROXIDASE-RELATED
357 634 Gene3D G3DSA:1.10.760.10 -
357 634 InterPro IPR036909 Cytochrome c-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2077
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.669
1 0.523