Protein profile

PA2078

hypothetical protein

Genome: NC_002516.2

Gene: PA2078 Structure source: AlphaFold UniProt Q9I237
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Amino acids 624
Annotations 5
Features 18
PDB binders 0
Druggability 0.725

Overview

Basic information about this protein and its source genome.

Accession
PA2078
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2078
Status
annotated
Amino acids
624
Structure source
AlphaFold
GO
GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion. GO:0031408 The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.725
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MHPTFSRVLLAAALAAAGSPAVATEIQLEQGWNAEQRASWYDASLGSRLLPLAWAQALERPDSEERLFSEDNARRLGFPLRNWQGGELRLPRGFALDQQDDSQFSDTRLRWKARQSSSEPWVGLNCAGCHSTDISYRGSELTVDAGATLANVQAIFDEVLAALRRTSDDGDKFARFAGNVLGSEDSPANRELLKAALVKRAALIDTLLSMSATDLQPGPGRLDATGQSLNRAAINSGARHLQANPTDAPTSFPALWHTLQMDKLQSSGFVPNVKVLDLNGQVFDLGYLAGDIGVVQGDYGDVVSHPLSGLEGYISSIRVDNLTRVEGLIHKLKAPAWPSQLFGAPDSARLAQGKRLYEENCAACHASIGRDDLQTPIKVRQVRLKAHGDDAPIGTDPWMACNTFTFSSPSGNYFGLFRPSLGTPSGVGIVGRTSKIADMQVPEVFQIMLGKKGQLADGIAEIIHAIVTGQQTLPGSDSLQAVPAGQLLLAGAAPADSQAQSLAAGEVPTDKSARKDYCLNTEHPFLGYIARPLNGIWATAPYLHNGSVPSLYDLLLPQEQRPATFYTGSHEFDPSRVGYLTAPGPDNAFLFDTHLEGNSNAGHDFAREYDESQRLALLEYLKTL

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0004130 Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O.
  • GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0046872 Binding to a metal ion.
  • GO:0031408 The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
8 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 624 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32 623 NCBIfam NF040606 di-heme-cytochrome C peroxidase
32 623 InterPro IPR047758 Di-heme-cytochrome C peroxidase
333 410 Gene3D G3DSA:1.10.760.10 -
333 410 InterPro IPR036909 Cytochrome c-like domain superfamily
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
348 624 ProSiteProfiles PS51007 Cytochrome c family profile.
348 624 InterPro IPR009056 Cytochrome c-like domain
5 624 PANTHER PTHR30600 CYTOCHROME C PEROXIDASE-RELATED
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
464 624 Gene3D G3DSA:1.10.760.10 -
464 624 InterPro IPR036909 Cytochrome c-like domain superfamily
344 624 SUPERFAMILY SSF46626 Cytochrome c
344 624 InterPro IPR036909 Cytochrome c-like domain superfamily
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2078
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.725
2 0.709
5 0.204