Protein profile

PA2101

hypothetical protein

Genome: NC_002516.2

Gene: PA2101 Structure source: AlphaFold UniProt Q9I214
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Amino acids 296
Annotations 1
Features 40
PDB binders 0
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
PA2101
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2101
Status
annotated
Amino acids
296
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
271 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
90 113 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
92 114 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
148 170 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
150 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
213 235 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
243 262 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 89 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 284 PANTHER PTHR32322 INNER MEMBRANE TRANSPORTER
177 201 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
202 212 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
34 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
290 296 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
65 84 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
65 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
266 270 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
242 265 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
114 119 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
190 287 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
119 138 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 284 Pfam PF00892 EamA-like transporter family
151 284 InterPro IPR000620 EamA domain
7 138 Pfam PF00892 EamA-like transporter family
7 138 InterPro IPR000620 EamA domain
139 149 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
272 294 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
120 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
236 241 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
171 176 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 142 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
214 236 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
54 64 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
19 33 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 52 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2101
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.839
2 0.589