Protein profile

PA2116

hypothetical protein

Genome: NC_002516.2

Gene: PA2116 Structure source: AlphaFold UniProt Q9I1Z9
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Amino acids 265
Annotations 2
Features 12
PDB binders 0
Druggability 0.652

Overview

Basic information about this protein and its source genome.

Accession
PA2116
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2116
Status
annotated
Amino acids
265
Structure source
AlphaFold
EC
4.2.1.-
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
32.184
Human E-value
5.27e-06
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.652
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 1 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

1
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
127 239 Gene3D G3DSA:3.30.2040.10 -
8 261 PANTHER PTHR32022 D-GLUTAMATE CYCLASE, MITOCHONDRIAL
117 259 Pfam PF07286 D-glutamate cyclase
117 259 InterPro IPR009906 D-glutamate cyclase
3 265 PIRSF PIRSF029755 UCP029755
3 265 InterPro IPR016938 Uncharacterised protein family UPF0317
127 239 FunFam G3DSA:3.30.2040.10:FF:000001 D-glutamate cyclase, mitochondrial
13 264 Hamap MF_01830 Putative hydro-lyase <locus_tag>.
13 264 InterPro IPR016938 Uncharacterised protein family UPF0317
18 256 Gene3D G3DSA:3.40.1640.10 -
10 259 SUPERFAMILY SSF160920 PSTPO5379-like
10 259 InterPro IPR038021 Putative hydro-lyase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2116
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.652
7 0.269