Protein profile

PA2122

hypothetical protein

Genome: NC_002516.2

Gene: PA2122 Structure source: AlphaFold UniProt Q9I1Z3
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Amino acids 378
Annotations 3
Features 18
PDB binders 0
Druggability 0.632

Overview

Basic information about this protein and its source genome.

Accession
PA2122
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA2122
Status
annotated
Amino acids
378
Structure source
AlphaFold
GO
GO:0005506 Binding to an iron (Fe) ion. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008610 The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.632
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPTMSFDPQPFRQQYRAAIRPGYNPWLHAGFVLAYGGAWIVFFLSRLEQPSLLEWLTVPAALVFFNWGEYRIHKSLGHHKHPLGRMFYKRHTGDHHSFFVAGQMRYEQARDWRVILFPAWLVVVFSLGALLAWSLLGLLNDNLAALFAATLLLGYLSYEIFHACEHLPPEHPLSRLPWIRHMRRLHELHHRRELMQTHNFNLVFPLMDWCYGTLHWEAETAEEHAMTRMQHRIEIARGPEATLAYAASPGLWPEWHPSSLRVDGAAGPLPAGARFEEDIHAGGRAGHLSWTVVEYQPGHLWRANARGDRGLHLRLSYECQPSAAGTRFVRTLEYRFDGWSMRLANLFLLRRRIERESEESMHRLRRVAEARIAAAESV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005506 Binding to an iron (Fe) ion.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0008610 The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
26 44 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
137 141 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 25 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114 136 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
226 371 SUPERFAMILY SSF55961 Bet v1-like
226 369 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport
226 369 InterPro IPR019587 Polyketide cyclase/dehydrase
114 136 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
45 113 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60 213 Pfam PF04116 Fatty acid hydroxylase
60 213 InterPro IPR006694 Fatty acid hydroxylase
162 378 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
53 70 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
225 376 Gene3D G3DSA:3.30.530.20 -
225 376 InterPro IPR023393 START-like domain superfamily
229 348 CDD cd07812 SRPBCC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2122
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.632
2 0.608