Protein profile

PA2127

hypothetical protein

Genome: NC_002516.2

Gene: PA2127 Structure source: AlphaFold UniProt Q9I1Y8

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Amino acids 408

Annotations 2

Features 10

PDB binders 0

Druggability 0.505

Overview

Basic information about this protein and its source genome.

Accession: PA2127
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2127
Status: annotated
Amino acids: 408
Structure source: AlphaFold

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.505

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
29	245	Pfam	PF01507	Phosphoadenosine phosphosulfate reductase family
29	245	InterPro	IPR002500	Phosphoadenosine phosphosulphate reductase
28	248	CDD	cd01713	PAPS_reductase
28	248	InterPro	IPR002500	Phosphoadenosine phosphosulphate reductase
4	251	Gene3D	G3DSA:3.40.50.620	HUPs
4	251	InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
247	348	Pfam	PF11922	Domain of unknown function (DUF3440)
247	348	InterPro	IPR021845	Protein of unknown function DUF3440
1	407	PANTHER	PTHR30083	UNCHARACTERIZED
5	243	SUPERFAMILY	SSF52402	Adenine nucleotide alpha hydrolases-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2127	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.505
5				0.406