Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2130
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: cupA3 PA2130
Status: annotated
Amino acids: 872
Structure source: AlphaFold

GO

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0098743 The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.582

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
GO:0098743 The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation.
GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records

Show feature table

Start	End	DB	Term	Name
4	859	PANTHER	PTHR30451	OUTER MEMBRANE USHER PROTEIN
4	859	InterPro	IPR000015	Outer membrane usher protein
1	10	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
34	157	SUPERFAMILY	SSF141729	FimD N-terminal domain-like
34	157	InterPro	IPR037224	PapC, N-terminal domain superfamily
312	322	ProSitePatterns	PS01151	Fimbrial biogenesis outer membrane usher protein signature.
312	322	InterPro	IPR018030	Fimbrial membrane usher, conserved site
686	776	FunFam	G3DSA:2.60.40.2610:FF:000001	Outer membrane fimbrial usher protein
270	359	Gene3D	G3DSA:2.60.40.3110	-
687	776	Gene3D	G3DSA:2.60.40.2610	Outer membrane usher protein FimD, plug domain
687	776	InterPro	IPR042186	Outer membrane usher protein FimD, plug domain
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	30	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
780	843	Pfam	PF13953	PapC C-terminal domain
780	843	InterPro	IPR025949	PapC-like, C-terminal domain
50	168	Gene3D	G3DSA:3.10.20.410	-
50	168	InterPro	IPR037224	PapC, N-terminal domain superfamily
23	30	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
11	22	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
197	771	Pfam	PF00577	Outer membrane usher protein
197	771	InterPro	IPR000015	Outer membrane usher protein
1	30	Phobius	SIGNAL_PEPTIDE	Signal peptide region
31	872	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
779	870	Gene3D	G3DSA:2.60.40.2070	-
779	870	InterPro	IPR043142	PapC-like, C-terminal domain superfamily
35	179	Pfam	PF13954	PapC N-terminal domain
35	179	InterPro	IPR025885	PapC, N-terminal domain
270	359	FunFam	G3DSA:2.60.40.3110:FF:000001	Putative fimbrial outer membrane usher
12	34	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2130	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.582
10				0.24

PA2130