Protein profile

PA2131

fimbrial subunit CupA4

Genome: NC_002516.2

Gene: cupA4 PA2131 Structure source: AlphaFold UniProt Q9I1Y4
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Amino acids 453
Annotations 3
Features 15
PDB binders 0
Druggability 0.767

Overview

Basic information about this protein and its source genome.

Accession
PA2131
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
cupA4 PA2131
Status
annotated
Amino acids
453
Structure source
AlphaFold
GO
GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.767
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
  • GO:0071453 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
7 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
274 451 SUPERFAMILY SSF49401 Bacterial adhesins
274 451 InterPro IPR008966 Adhesion domain superfamily
24 453 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 SignalP_EUK SignalP-noTM SignalP-noTM
7 453 PIRSF PIRSF029766 UCP029766
7 453 InterPro IPR011228 Uncharacterised conserved protein UCP029766
267 453 Pfam PF00419 Fimbrial protein
267 453 InterPro IPR000259 Fimbrial-type adhesion domain
273 452 Gene3D G3DSA:2.60.40.1090 -
273 452 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA2131
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.767
3 0.601
2 0.292