Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2148
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2148
Status: annotated
Amino acids: 163
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.882

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records

Show feature table

Start	End	DB	Term	Name
108	130	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
56	73	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
74	84	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
45	55	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27	44	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
51	73	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
105	110	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27	44	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
83	101	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
154	163	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
109	133	PRINTS	PR01837	MgtC/SapB protein signature
109	133	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
34	53	PRINTS	PR01837	MgtC/SapB protein signature
34	53	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
53	71	PRINTS	PR01837	MgtC/SapB protein signature
53	71	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
80	102	PRINTS	PR01837	MgtC/SapB protein signature
80	102	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
85	104	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
22	154	PANTHER	PTHR33778	PROTEIN MGTC
22	154	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
131	135	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
111	130	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
134	153	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
31	155	Pfam	PF02308	MgtC family
31	155	InterPro	IPR003416	MgtC/SapB/SrpB/YhiD family
136	153	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	26	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2148	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.882

PA2148