Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA2150
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA2150 ku
Status: annotated
Amino acids: 293
Structure source: AlphaFold

GO

GO:0003690 Binding to double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006303 The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. GO:0051351 Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.894

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003690 Binding to double-stranded DNA.
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
GO:0006303 The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
GO:0051351 Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records

Show feature table

Start	End	DB	Term	Name
2	262	NCBIfam	TIGR02772	Ku protein
2	262	InterPro	IPR009187	Non-homologous end joining protein Ku, prokaryotic type
2	259	SUPERFAMILY	SSF100939	SPOC domain-like
2	259	InterPro	IPR016194	SPOC-like, C-terminal domain superfamily
260	293	MobiDBLite	mobidb-lite	consensus disorder prediction
22	29	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	29	Phobius	SIGNAL_PEPTIDE	Signal peptide region
10	21	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
4	179	FunFam	G3DSA:2.40.290.10:FF:000004	Non-homologous end joining protein Ku
2	260	Hamap	MF_01875	Non-homologous end joining protein Ku [ku].
2	260	InterPro	IPR009187	Non-homologous end joining protein Ku, prokaryotic type
30	293	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12	193	Pfam	PF02735	Ku70/Ku80 beta-barrel domain
12	193	InterPro	IPR006164	Ku70/Ku80 beta-barrel domain
1	23	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
53	181	SMART	SM00559	ku_4
53	181	InterPro	IPR006164	Ku70/Ku80 beta-barrel domain
3	181	Gene3D	G3DSA:2.40.290.10	-
3	181	InterPro	IPR016194	SPOC-like, C-terminal domain superfamily
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	29	SignalP_EUK	SignalP-noTM	SignalP-noTM
1	291	PANTHER	PTHR41251	NON-HOMOLOGOUS END JOINING PROTEIN KU
1	291	InterPro	IPR009187	Non-homologous end joining protein Ku, prokaryotic type
260	279	MobiDBLite	mobidb-lite	consensus disorder prediction
3	260	CDD	cd00789	KU_like
3	260	InterPro	IPR009187	Non-homologous end joining protein Ku, prokaryotic type
1	292	PIRSF	PIRSF006493	Prok_Ku
1	292	InterPro	IPR009187	Non-homologous end joining protein Ku, prokaryotic type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA2150	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
5				0.894
1				0.664

PA2150